Cyclophilin A Is Localized to the Nucleus and Controls Meiosis in Saccharomyces cerevisiae

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Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae.

Cyclophilin A is conserved from yeast to humans and mediates the ability of cyclosporine to perturb signal transduction cascades via inhibition of calcineurin. Cyclophilin A also catalyzes cis-trans peptidyl-prolyl isomerization during protein folding or conformational changes; however, cyclophilin A is not essential in yeast or human cells, and the true biological functions of this highly cons...

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ژورنال

عنوان ژورنال: Eukaryotic Cell

سال: 2005

ISSN: 1535-9778,1535-9786

DOI: 10.1128/ec.4.1.17-29.2005